Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo

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If there’s a recipe that screams indulgent comfort with a spicy twist, it’s this Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo. Tender twisted pasta clings to a luxurious Alfredo sauce infused with Cajun spices, while juicy seared chicken brings hearty satisfaction to every bite. The mozzarella adds a creamy pull that makes the dish not only delicious but delightfully cheesy.

This dish blends Southern flair with Italian richness in the most irresistible way. It’s a dinner that feels gourmet but is actually weeknight-friendly. You get the spice, the creaminess, the protein, and the pasta all in one pan—a dream combination that quickly becomes a go-to when you’re craving bold flavor without complicated steps.

Why You’ll Love This Creamy Cajun Chicken Twisted Pasta

It’s rich, bold, and packed with flavor from the first forkful. The Cajun seasoning adds just the right amount of heat and depth without overwhelming the creamy mozzarella Alfredo. The twisted pasta holds onto the sauce beautifully, and the seared chicken ensures that every bite is loaded with savory goodness. Plus, this dish comes together in under 40 minutes, making it perfect for both weeknights and special occasions.

What Kind of Pasta Should I Use?

For this dish, twisted pasta like rotini, cavatappi, or fusilli is ideal. These shapes are designed to hug creamy sauces and give every bite a consistent texture. They also hold up well to being tossed with seared chicken and mozzarella, ensuring that nothing gets lost at the bottom of the bowl. If you’re in a pinch, penne or rigatoni can work too, but try to stick to twists for maximum sauce cling and texture.

Ingredients for the Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo

To bring this creamy Cajun dream to life, you only need a handful of everyday ingredients. Each one plays an important role in building the layers of flavor, texture, and richness.

• Twisted pasta
• Chicken breasts
• Cajun seasoning
• Heavy cream
• Mozzarella cheese
• Garlic
• Butter
• Olive oil
• Parmesan cheese
• Salt & pepper

How To Make the Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo

Step 1: Prep and Season the Chicken

Slice the chicken breasts into strips or bite-sized pieces. Coat them generously with Cajun seasoning, salt, and pepper. Let them sit for 5–10 minutes to absorb the flavors.

Step 2: Cook the Pasta

Bring a large pot of salted water to a boil and cook your twisted pasta until al dente. Reserve half a cup of pasta water before draining.

Step 3: Sear the Chicken

In a large skillet over medium heat, add a mix of butter and olive oil. Sear the chicken until golden and fully cooked through, about 5–7 minutes. Remove from skillet and set aside.

Step 4: Build the Alfredo Base

In the same skillet, add minced garlic and a bit more butter. Let it sizzle until fragrant, then pour in the heavy cream. Simmer gently and stir in mozzarella and parmesan cheese. Add a touch of Cajun seasoning for extra depth.

Step 5: Combine Everything

Toss the drained pasta into the Alfredo sauce and stir in the cooked chicken. If needed, use the reserved pasta water to loosen the sauce until it reaches your desired creaminess. Let everything warm together for a minute or two.

Step 6: Serve and Garnish

Plate your pasta hot and creamy, optionally topped with extra parmesan, fresh parsley, or even a pinch of red pepper flakes for a touch more heat.

Serving and Storing Your Creamy Cajun Chicken Pasta

This dish is best served hot right after everything is tossed together, when the mozzarella is still gooey and the Alfredo sauce is silky. It feeds around 4 people generously, making it a great option for small gatherings or weeknight family dinners. If you have leftovers, store them in an airtight container in the fridge for up to 3 days. Reheat gently over the stove or in the microwave, adding a splash of milk or cream to bring back the creamy texture.

What to Serve With Creamy Cajun Chicken Pasta?

Garlic Bread with Herbs

A crispy side of garlic bread is always a win. It complements the creamy sauce and helps scoop up any leftovers in the bowl.

Simple Arugula Salad

The peppery flavor of arugula with a lemon vinaigrette balances the richness of the pasta beautifully.

Roasted Broccoli

Tossed in olive oil and sea salt, roasted broccoli adds a touch of earthiness and crunch.

Cajun Corn on the Cob

Add extra Cajun flair by serving charred corn seasoned with butter and Cajun spice.

Sauteed Green Beans

Fresh green beans with a little garlic and butter provide a crisp contrast to the creamy pasta.

Tomato Cucumber Salad

Bright and refreshing, this chilled salad lightens the meal and adds a cool crunch.

Crusty Artisan Bread

Great for soaking up every last bit of Alfredo sauce on the plate.

Sparkling Water with Citrus

A light and fizzy drink helps cut through the creamy richness and refresh your palate.

Want More Pasta Ideas?

If you’re into creamy and bold pasta dishes, here are more recipes that bring comfort and creativity to the table:

• Try our Delicious Garlic Sausage Alfredo Rigatoni if you’re craving garlicky goodness with a cheesy finish.
• This Quick Creamy Cajun Pasta is perfect when you want those flavors fast.
• For a veggie-forward twist, the Creamy Mushroom Ravioli delivers cozy umami in every bite.
• Or mix it up with Cowboy Butter Chicken Linguine for that savory herbed kick.
• And don’t miss the spicy-sweet balance in our Fiery Chicken Ramen with Creamy Garlic Sauce.

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And let me know in the comments how yours turned out. Did you add extra heat or swap the cheese? Maybe you used shrimp instead of chicken?

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Conclusion

Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo is a celebration of flavor and texture. It checks all the boxes—hearty, spicy, creamy, and irresistibly cheesy. Whether you’re cooking for your family or entertaining guests, this dish brings big flavor with ease. Keep it in your rotation for when you need a reliable recipe that satisfies every craving in one pot.

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