Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce

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There’s something irresistibly comforting about a rich, creamy bowl of pasta, and when it gets a kick of Cajun spice and tender seared chicken? That’s dinner bliss. This creamy Cajun chicken rotini is a flavor-packed twist on a classic Alfredo, featuring smoky seasoning, juicy bites of chicken, and a smooth mozzarella Alfredo sauce that clings to every curl of rotini.

Perfect for weeknights when you want something satisfying without too much fuss, this dish brings together spice and cream in a balanced way. The Cajun seasoning adds just enough heat to excite your taste buds, while the mozzarella Alfredo sauce brings a velvety, cheesy comfort that makes it hard to put the fork down.

Why You’ll Love This Creamy Cajun Chicken Rotini

This recipe is a true one-pan wonder. It combines protein, carbs, and flavor into a hearty meal that doesn’t require endless prep. The Cajun flavor gives it a bold personality, making it more exciting than your average Alfredo dish. Plus, rotini pasta is perfect here – all those little spirals soak up the sauce beautifully, giving you the perfect bite every time. It’s also endlessly customizable: toss in some spinach, mushrooms, or sun-dried tomatoes if you’re feeling creative.

What Kind of Cajun Seasoning Should I Use?

Not all Cajun blends are created equal, so choose one that has the balance of paprika, garlic powder, onion powder, cayenne, and thyme. You can go for store-bought if you’re in a rush, or make your own at home if you like more control over the spice level. For a spicier kick, look for one that leans heavier on cayenne pepper. Just be sure to taste as you go – Cajun seasoning can be punchy, and it’s better to build flavor gradually than to go overboard.

Ingredients for the Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce

To make this creamy and spicy pasta dish a success, you need ingredients that balance richness with bold flavor. The Cajun seasoning brings heat and smokiness, while the mozzarella Alfredo sauce smooths it out with cheesy comfort. This combination creates a crave-worthy sauce that transforms simple rotini into a weeknight favorite.

• Chicken breast
• Rotini pasta
• Olive oil
• Cajun seasoning
• Garlic
• Butter
• Heavy cream
• Mozzarella cheese
• Parmesan cheese
• Salt and pepper
• Fresh parsley (optional for garnish)

How To Make the Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce

Step 1: Cook the Pasta

Bring a large pot of salted water to a boil and cook the rotini according to package instructions until al dente. Drain and set aside.

Step 2: Season and Sear the Chicken

While the pasta cooks, cut the chicken breasts into bite-sized pieces. Season generously with Cajun seasoning, salt, and pepper. Heat olive oil in a skillet over medium heat and cook the chicken until golden and cooked through. Remove from the pan and set aside.

Step 3: Build the Sauce Base

In the same pan, melt butter and add minced garlic. Sauté for 1 minute until fragrant, then pour in the heavy cream. Stir and let it simmer for 3-4 minutes to thicken slightly.

Step 4: Stir in the Cheese

Reduce the heat to low and stir in shredded mozzarella and grated Parmesan. Stir constantly until the cheeses are fully melted and the sauce is smooth.

Step 5: Combine and Serve

Return the cooked chicken to the pan along with the drained rotini. Toss everything together until well coated. Let it simmer for another 2 minutes so the flavors meld. Garnish with fresh parsley and serve hot.

How to Serve and Store Creamy Cajun Chicken Rotini

This dish is best served hot straight from the skillet, when the sauce is silky and the pasta is still bouncy. It easily feeds 4 hungry people, making it great for families or a small gathering. If you want to stretch it, serve it with a side salad or some garlic bread to round out the meal.

To store leftovers, let the pasta cool completely before transferring to an airtight container. It will keep in the fridge for up to 3 days. When reheating, add a splash of cream or milk to loosen the sauce and warm gently on the stove or in the microwave. Avoid overheating to preserve the texture of the cheese sauce.

What to Serve With Creamy Cajun Chicken Rotini?

Garlic Bread with Herbs

The buttery crunch of garlic bread is the perfect contrast to the creamy pasta. Use fresh herbs like parsley or oregano to add a burst of flavor.

Roasted Broccoli or Asparagus

Roasting brings out the sweetness in these green veggies and adds a nice textural balance to the pasta’s richness.

Caesar Salad

The crispness and tang of a Caesar salad offer a refreshing counterpoint to the warm, cheesy sauce.

Creamed Spinach

If you’re doubling down on comfort, creamed spinach is a luxurious side that pairs well with Cajun spices.

Tomato Cucumber Salad

Bright and juicy, this side helps cut through the heaviness and brings a fresh bite to your plate.

Cornbread Muffins

Slightly sweet and crumbly, cornbread muffins complement the spiciness of the Cajun chicken beautifully.

Sautéed Mushrooms

Earthy and savory, mushrooms go well with both the chicken and Alfredo elements of this dish.

Avocado Slices or Guacamole

It might sound unconventional, but creamy avocado offers a cooling balance to the heat of the Cajun seasoning.

Want More Pasta Ideas with a Kick?

If you can’t get enough of this Creamy Cajun Chicken Rotini, you’re going to love these bold, flavor-packed recipes that bring variety to the table while still keeping things easy and delicious:

• Try the Quick Creamy Cajun Pasta Recipe for a weeknight-friendly version that’s just as rich and spicy.
• Dig into Delicious Garlic Sausage Alfredo Rigatoni if you want to swap chicken for savory sausage and explore a garlicky twist.
• Explore this satisfying Easy Chicken Fried Rice if you’re craving something fast and filling with an Asian flair.
• Add this Crockpot Loaded Steak and Potato Bake to your dinner rotation when you want something hearty without the stovetop.
• Or keep it classic with the Creamy Mushroom Sauce for Steak that’s perfect for date nights or indulgent weekend dinners.

Save This Recipe For Later

📌 Save this recipe to your Pinterest dinner board so you can come back to it any time.

And let me know in the comments how yours turned out. Did you dial up the Cajun heat or keep it mild? Did you sneak in some extra veggies or add a sprinkle of red pepper flakes?

I love hearing how others make these recipes their own. Feel free to ask questions too – let’s help each other cook better, one spicy, creamy bowl at a time.

Explore beautifully curated dinner and comfort food recipes on Luna Meals on Pinterest and discover your next weeknight favorite.

Conclusion

Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce is a dish that hits every note – spicy, creamy, comforting, and quick enough to whip up on a busy evening. The Cajun spices bring warmth and flavor, while the mozzarella Alfredo adds that irresistible cheesy creaminess that makes every bite satisfying. This one is sure to be a repeat in your recipe rotation.

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