Cajun Chicken Spaghetti in Creamy Garlic Mozzarella Sauce

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Bold, fiery, and irresistibly creamy, this Cajun Chicken Spaghetti in Creamy Garlic Mozzarella Sauce is what pasta dreams are made of. Perfectly seasoned chicken is seared until golden, then tossed with spaghetti and smothered in a velvety garlic mozzarella sauce that clings to every strand. Each bite packs a satisfying punch of Cajun spice balanced with mellow creaminess, making it both comforting and exciting.

This dish is your new weeknight hero. It comes together quickly and doesn’t skimp on flavor. Whether you’re feeding your family or looking to impress guests, this pasta delivers big time. It brings that Southern flair with just the right kick, and the best part? It’s all made in one pan, making cleanup a breeze.

Why You’ll Love This Cajun Chicken Spaghetti

If you crave creamy pasta with a spicy edge, this one checks all the boxes. It’s incredibly flavorful without being overwhelming. The Cajun seasoning adds heat, the garlic gives depth, and the mozzarella melts into a silky sauce that wraps everything in indulgent warmth. Add juicy chicken and tender spaghetti to the mix, and it’s the kind of meal that makes you want seconds immediately.

This recipe is also flexible. Swap in fettuccine, penne, or even gluten-free pasta. Prefer shrimp instead of chicken? Go for it. It’s a forgiving base that welcomes your kitchen creativity.

What Kind of Spaghetti Should I Use?

For this Cajun Chicken Spaghetti, classic durum wheat spaghetti is ideal because it holds up well to the thick, cheesy sauce. You can also opt for whole wheat pasta for a bit more fiber and a heartier chew, or use gluten-free varieties if needed. What matters most is cooking it al dente so it doesn’t get mushy in the sauce. Don’t forget to reserve a bit of that starchy pasta water—it helps the sauce cling to the noodles beautifully.

Ingredients for the Cajun Chicken Spaghetti in Creamy Garlic Mozzarella Sauce

A big reason this pasta is such a crowd-pleaser is thanks to its simple yet impactful ingredients. Everything in this dish serves a purpose—from building a robust base of flavor to creating a rich, creamy sauce that’s loaded with character. Here’s what you’ll need:

• Chicken breast
• Cajun seasoning
• Olive oil
• Garlic cloves
• Heavy cream
• Mozzarella cheese
• Parmesan cheese
• Spaghetti
• Butter
• Salt and pepper

The chicken breast is your protein star—tender, juicy, and ideal for soaking up bold Cajun spices. Cajun seasoning gives the dish its signature heat and Southern charm. A little olive oil helps sear the chicken to golden perfection.

Garlic cloves bring an aromatic punch that deepens the flavor of the creamy sauce. Heavy cream makes the sauce irresistibly smooth and rich, while mozzarella cheese adds that stretchy, melty comfort. A touch of Parmesan cheese layers in salty, nutty depth.

Classic spaghetti is the vehicle for all that flavor, and butter adds richness right at the finish. Don’t forget salt and pepper to balance everything and make those flavors pop.

How To Make the Cajun Chicken Spaghetti in Creamy Garlic Mozzarella Sauce

Step 1: Season and Cook the Chicken

Slice the chicken breasts into bite-sized strips and coat them generously with Cajun seasoning. Heat olive oil in a large skillet and sear the chicken over medium-high heat until golden and fully cooked through. Set the chicken aside.

Step 2: Cook the Pasta

Bring a large pot of salted water to a boil and cook the spaghetti until al dente. Reserve a cup of pasta water before draining.

Step 3: Build the Creamy Garlic Sauce

In the same skillet used for the chicken, melt butter and sauté minced garlic until fragrant. Pour in the heavy cream and bring it to a gentle simmer. Stir in mozzarella and Parmesan cheese until melted and smooth. Season with salt and pepper to taste.

Step 4: Combine Everything

Return the cooked chicken to the pan, then add the cooked spaghetti. Toss everything together, adding a splash of reserved pasta water if needed to thin the sauce and help it coat the noodles.

Step 5: Serve Hot

Plate the pasta immediately while it’s creamy and hot. Garnish with a sprinkle of extra Parmesan or chopped parsley if you like.

Serving and Storing Cajun Chicken Spaghetti in Creamy Garlic Mozzarella Sauce

This dish is best served piping hot straight from the skillet, when the cheese is perfectly melty and the sauce hugs every strand of spaghetti. It comfortably feeds about four people, making it perfect for a cozy family dinner or an easy entertaining option.

Leftovers store well in an airtight container in the fridge for up to 3 days. The sauce may thicken as it cools, but a splash of milk or cream when reheating brings it right back to life. To reheat, use a skillet over low heat or microwave in short bursts, stirring in between.

What to Serve With Cajun Chicken Spaghetti?

Garlic Bread

Buttery, garlicky, and crisp on the edges, garlic bread is the ultimate sidekick to scoop up every last bit of that creamy sauce.

Steamed Broccoli

The freshness and light crunch of steamed broccoli adds balance to the rich pasta and makes for a nutritious, colorful plate.

Caesar Salad

Crisp romaine, Parmesan, and creamy Caesar dressing offer a cool and zesty contrast that cuts through the richness beautifully.

Roasted Brussels Sprouts

Tossed with olive oil and roasted until caramelized, these bring earthy flavor that pairs well with Cajun spices.

Cornbread Muffins

A Southern-inspired side that complements the spice with subtle sweetness and a soft crumb.

Grilled Asparagus

Lightly charred asparagus spears bring a bit of smokiness and brightness to the meal.

Pickled Vegetables

For something tangy and sharp to offset the creaminess, quick-pickled cucumbers or onions work surprisingly well.

Iced Tea or Lemonade

To drink, a tall glass of unsweetened iced tea or lemonade cools the palate and rounds out the Southern comfort vibes.

Want More Chicken Pasta Ideas?

If you loved this Cajun Chicken Spaghetti in Creamy Garlic Mozzarella Sauce, you’ll probably fall in love with these other hearty and flavor-packed dishes from Luna Meals:

• Delicious Garlic Sausage Alfredo Rigatoni for a creamy, garlicky twist with savory sausage.
• Easy Chicken Fried Rice if you’re craving something fast, flavorful, and loaded with veggies.
• Creamy Kielbasa Gnocchi Soup for a cozy one-bowl meal.
• BBQ Chicken Pizza to keep the chicken theme going with bold BBQ flavor.
• Pepperoni Pizza Grilled Cheese when you’re in the mood for melty, cheesy indulgence.

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And let me know in the comments how yours turned out! Did you go heavy on the Cajun spice or keep it mild? Maybe you tried it with shrimp instead of chicken?

I love hearing how others make these recipes their own. Questions are always welcome, and your feedback helps everyone cook better at home.

Explore beautifully curated health-boosting and comforting meals on Luna Meals on Pinterest and discover your new go-to dinner inspiration!

Conclusion

Cajun Chicken Spaghetti in Creamy Garlic Mozzarella Sauce is the kind of dish that hits every note: creamy, spicy, comforting, and packed with bold flavor. Whether you’re feeding a crowd or treating yourself to a cozy night in, this recipe brings restaurant-level quality right to your home kitchen. It’s a keeper—one you’ll want to make again and again.

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