If comfort food had a spicy, cheesy, heartwarming cousin, this would be it. Creamy Mozzarella Rotini with Spicy Cajun Beef and Velveeta Sauce delivers bold Southern heat balanced by the richness of velvety cheese and tender pasta. It’s the kind of meal that satisfies every craving: creamy, savory, cheesy, and a little spicy.

The blend of Cajun-seasoned beef and Velveeta creates a saucy, decadent base that clings to every spiral of rotini. Finished with mozzarella for that melty pull, this dish is indulgent without being overwhelming. It’s a one-pot wonder you’ll want to make again and again.

Why You’ll Love This Creamy Mozzarella Rotini with Spicy Cajun Beef and Velveeta Sauce

This recipe comes together fast but delivers a flavor that tastes like it simmered for hours. The spiced beef gives a nice kick without being too fiery, and Velveeta’s smooth meltability ensures the sauce stays silky without effort. Mozzarella adds that stretchy gooeyness we all crave, making every bite irresistibly cheesy. And since rotini traps all the saucy goodness in its curls, you’re guaranteed flavor in every forkful.

This is a dinner that’s weeknight-easy yet guest-worthy. It’s filling, fuss-free, and customizable for different spice levels or proteins. Plus, the leftovers are dreamy reheated.

What Kind of Pasta Works Best for This Dish?

Rotini is the top pick for a reason. Its spirals grab onto every bit of the creamy Cajun Velveeta sauce, ensuring nothing goes to waste. But if you’re out of rotini, you can substitute with penne, fusilli, or even elbow macaroni in a pinch. Just avoid long noodles like spaghetti or linguine, which don’t hold the sauce as well. For a little extra nutrition, whole wheat or protein-enriched pasta is a great alternative too.

Ingredients for the Creamy Mozzarella Rotini with Spicy Cajun Beef and Velveeta Sauce

This creamy, cheesy pasta starts with a few pantry staples, elevated by bold flavors and smart pairings. Each ingredient plays a unique role in creating that signature balance of creamy, spicy, and savory. Here’s what you’ll need:

Rotini pasta
Ground beef
Cajun seasoning

Garlic
Onion
Velveeta cheese

Mozzarella cheese
Milk
Butter

Olive oil
Salt and black pepper

Rotini pasta holds the sauce perfectly in its spirals, making each bite flavor-packed.

Ground beef adds hearty protein and soaks up the Cajun spices beautifully.

Cajun seasoning is where the bold kick comes from. Adjust to taste for your preferred heat level.

Garlic and onion form a flavorful base that enhances everything else in the pot.

Velveeta cheese brings that nostalgic, ultra-creamy melt that coats every noodle.

Mozzarella cheese is the final cheesy flourish, adding that satisfying pull and gooey texture.

Milk loosens the sauce just enough while keeping it rich.

Butter and olive oil help to cook the aromatics and deepen the flavor.

A pinch of salt and pepper brings it all into balance.

Creamy Mozzarella Rotini with Spicy Cajun Beef and Velveeta Sauce 2

How To Make the Creamy Mozzarella Rotini with Spicy Cajun Beef and Velveeta Sauce

Step 1: Cook the Pasta

Bring a large pot of salted water to a boil and cook the rotini until al dente according to the package instructions. Drain and set aside.

Step 2: Brown the Beef

In a large skillet over medium-high heat, add a splash of olive oil. Toss in the ground beef and break it up with a spatula. Cook until browned and no longer pink. Drain any excess fat.

Step 3: Add Aromatics and Seasoning

Reduce the heat to medium and stir in the butter, chopped onion, and minced garlic. Cook for 3–4 minutes until fragrant and translucent. Add Cajun seasoning and stir to combine.

Step 4: Make the Cheese Sauce

Lower the heat and add cubed Velveeta and milk. Stir until the cheese is melted and the sauce is smooth and creamy.

Step 5: Combine Everything

Add the cooked rotini to the skillet and toss gently to coat with the sauce. Sprinkle shredded mozzarella over the top and stir it in just until melty.

Step 6: Serve Hot

Spoon into bowls while piping hot and enjoy that melty, spicy, creamy goodness!

How to Serve and Store Creamy Mozzarella Rotini with Spicy Cajun Beef and Velveeta Sauce

This creamy pasta dish is best served hot and fresh, straight from the skillet. The cheese is perfectly gooey, the beef tender, and the Cajun spice at its boldest right after cooking. It feeds about 4 to 6 people, making it a great option for family dinners or small gatherings.

If you’re prepping ahead or end up with leftovers, store the pasta in an airtight container in the fridge for up to 3 days. To reheat, simply warm on the stove with a splash of milk to loosen the sauce. It can also be microwaved in 30-second intervals, stirring in between, until thoroughly heated.

What to Serve With Creamy Mozzarella Rotini with Spicy Cajun Beef and Velveeta Sauce?

Garlic Bread

The crispy, buttery crunch of garlic bread is a perfect contrast to the creamy pasta. Plus, it helps scoop up every last bit of sauce.

Simple Green Salad

A refreshing salad with a tangy vinaigrette cuts through the richness and adds a fresh bite to the plate.

Roasted Broccoli

Earthy, slightly charred broccoli balances the spice and cream with a wholesome side that’s easy to make.

Sauteed Green Beans

Tossed in olive oil and a touch of lemon, green beans offer a crisp, zesty pairing.

Grilled Corn on the Cob

Sweet corn complements the Cajun flavors and adds a pop of summer to your dinner.

Crispy Fried Pickles

Unexpected? Sure. But the tangy crunch is a surprisingly fun and delicious contrast to the rich pasta.

Southern Coleslaw

Creamy and tangy with a hint of crunch, this adds a refreshing Southern touch that works beautifully with the bold beef.

Sweet Tea or Lemonade

Round it all out with a chilled glass of sweet tea or citrusy lemonade for that final Southern comfort vibe.

Want More Cheesy Pasta Ideas?

If you’re into cheesy, flavorful, and quick pasta dinners like this Creamy Mozzarella Rotini with Spicy Cajun Beef and Velveeta Sauce, you’ll definitely want to check out these crowd-pleasers from Luna Meals:

Try the Delicious Garlic Sausage Alfredo Rigatoni for a creamy, savory twist with a hint of garlic.
Craving something with shrimp? The Creamy Garlic Butter Shrimp Scampi Lasagna layers bold flavors in a rich pasta bake.

For a Southern comfort spin, go for the Dirty Rice with Ground Beef that brings heat and heartiness in every bite.
Need a quick Cajun fix? The Quick Creamy Cajun Pasta Recipe is perfect for busy weeknights.
And if you’re looking for a cozy beef-based bake, don’t miss the Crockpot Loaded Steak and Potato Bake.

Save This Recipe For Later

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And let me know in the comments how yours turned out. Did you spice it up more? Add bell peppers or a different cheese?

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Conclusion

Creamy Mozzarella Rotini with Spicy Cajun Beef and Velveeta Sauce is one of those dishes that hits every note: cheesy, spicy, creamy, and comforting. It’s fast enough for a weeknight but impressive enough for guests. Whether you’re cooking for family or just want to indulge in something satisfying and full of flavor, this pasta brings it all together in one delicious bowl.

Creamy Mozzarella Rotini with Spicy Cajun Beef and Velveeta Sauce

Why You’ll Love This Creamy Mozzarella Rotini with Spicy Cajun Beef and Velveeta Sauce

What Kind of Pasta Works Best for This Dish?

Ingredients for the Creamy Mozzarella Rotini with Spicy Cajun Beef and Velveeta Sauce