Creamy Cajun Chicken Rotini with Garlic Mozzarella Sauce

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If comfort food had a spicy, creamy cousin, it would be this Creamy Cajun Chicken Rotini with Garlic Mozzarella Sauce. This dish brings together the bold flavors of Cajun seasoning, tender chicken, and a luxuriously smooth mozzarella-infused sauce that hugs every twist of the rotini. The result is a pasta bowl that’s both satisfying and exciting with every bite.

Perfect for weeknights when you want something hearty but not complicated, this recipe is quick to prepare and guaranteed to please. The combination of creamy garlic mozzarella sauce and the gentle heat of Cajun spices creates a flavor profile that feels indulgent yet balanced. Plus, it’s a one-pan wonder that keeps cleanup simple.

Why You’ll Love This Creamy Cajun Chicken Rotini

You get the best of both worlds: comfort and kick. The pasta is coated in a sauce so creamy it could stand alone as a meal, yet the Cajun spices lift the whole dish with warmth and depth. It’s also incredibly versatile — you can add vegetables, swap proteins, or adjust the heat to suit your tastes.

What Type of Cajun Seasoning Works Best?

The magic of this recipe lies in the seasoning blend. A classic Cajun seasoning with a mix of paprika, garlic powder, onion powder, oregano, thyme, cayenne, and black pepper will do wonders. If you like things on the spicier side, go heavier on the cayenne or choose a “hot” Cajun mix. For a milder version, opt for a low-sodium blend so you can control the saltiness while still getting that signature flavor.

Ingredients for the Creamy Cajun Chicken Rotini with Garlic Mozzarella Sauce

This recipe calls for simple ingredients that come together to create layers of flavor. The Cajun seasoning brings heat and smokiness, the chicken adds heartiness, and the mozzarella transforms the sauce into something luxuriously creamy.

• Rotini pasta – Perfect for holding onto that rich, cheesy sauce.
• Boneless skinless chicken breasts – Tender protein that absorbs the Cajun spices beautifully.
• Cajun seasoning – The backbone of the dish’s bold, savory flavor.
• Olive oil – Helps sear the chicken and adds a subtle richness.
• Garlic cloves – Fresh garlic deepens the sauce’s flavor.
• Heavy cream – Gives the sauce a velvety texture.
• Mozzarella cheese – Melts into the sauce for that irresistible gooey pull.
• Chicken broth – Adds depth and prevents the sauce from being overly heavy.
• Salt and pepper – To balance the seasoning and highlight the flavors.
• Fresh parsley – A pop of green for freshness and color.

How To Make the Creamy Cajun Chicken Rotini with Garlic Mozzarella Sauce

Step 1: Season and Cook the Chicken

Slice the chicken breasts into bite-sized pieces and season generously with Cajun seasoning, salt, and pepper. Heat olive oil in a large skillet over medium-high heat and cook the chicken until golden on all sides and fully cooked through. Remove and set aside.

Step 2: Cook the Pasta

Bring a large pot of salted water to a boil and cook the rotini until al dente, according to package instructions. Drain and set aside, reserving about a cup of pasta water.

Step 3: Make the Garlic Mozzarella Sauce

In the same skillet used for the chicken, add a little more olive oil if needed and sauté minced garlic until fragrant. Pour in the chicken broth and heavy cream, stirring to combine. Reduce the heat to low and slowly stir in shredded mozzarella until the sauce is smooth and creamy.

Step 4: Combine Everything

Return the cooked chicken to the skillet, then add the drained pasta. Toss everything together until the rotini is well-coated in sauce. If the sauce is too thick, add a splash of the reserved pasta water.

Step 5: Garnish and Serve

Sprinkle with fresh parsley and a little extra Cajun seasoning if you like a stronger kick. Serve hot and enjoy immediately.

Serving and Storing Your Creamy Cajun Chicken Rotini with Garlic Mozzarella Sauce

This recipe is hearty enough to serve as a main course and makes about four generous portions. Serve it straight from the skillet for a cozy family meal, or plate it individually for a more elegant presentation. The creamy sauce thickens slightly as it cools, making every forkful just as satisfying.

If you have leftovers, store them in an airtight container in the refrigerator for up to three days. When reheating, add a splash of milk or chicken broth to loosen the sauce and restore its silky texture. This dish is best enjoyed fresh, but it reheats well for next-day lunches.

What to Serve With Creamy Cajun Chicken Rotini?

Garlic Bread

Warm, buttery garlic bread is perfect for scooping up extra sauce.

Roasted Vegetables

A mix of roasted bell peppers, zucchini, and asparagus adds color and balances the richness.

Simple Green Salad

A crisp salad with a light vinaigrette refreshes the palate between bites.

Cornbread

Sweet, crumbly cornbread is a comforting Southern-style side.

Sautéed Spinach

Quickly sautéed spinach with garlic complements the creamy pasta without overpowering it.

Grilled Shrimp

Add a protein boost and a touch of surf to your turf.

Creamy Coleslaw

A cool, crunchy contrast to the warm, cheesy pasta.

Want More Pasta Ideas?

If you love this Creamy Cajun Chicken Rotini with Garlic Mozzarella Sauce, you’ll probably enjoy these other favorites from Luna Meals:

• Delicious Garlic Sausage Alfredo Rigatoni for a savory twist packed with hearty flavor.
• Quick Creamy Cajun Pasta if you’re looking for a faster, equally delicious Cajun-inspired dinner.
• Creamy Mushroom Ravioli for a rich and earthy pasta night.
• Garlic Butter Chicken Balls with Creamy Parmesan Pasta for a fun, bite-sized twist.

Save This Recipe For Later

📌 Save this recipe to your Pinterest dinner board so you can come back to it any time.

And let me know in the comments how yours turned out. Did you add extra vegetables or more heat? Did you try swapping the protein? I love hearing how others make these recipes their own. Questions are welcome too — let’s help each other cook smarter.

Explore beautifully curated, flavor-packed recipes on Luna Meals on Pinterest and find your next weeknight winner.

Conclusion

Creamy Cajun Chicken Rotini with Garlic Mozzarella Sauce is the kind of meal that turns a regular night into something special. It’s creamy, comforting, and just the right amount of bold. Whether you make it for family dinner, a cozy date night, or meal prep, this dish is bound to become a favorite in your kitchen.

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