Creamy Cajun Chicken Pasta with Parmesan, Garlic, and Mozzarella

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If you’re craving a dinner that feels indulgent yet comes together with everyday ingredients, this Creamy Cajun Chicken Pasta with Parmesan, Garlic, and Mozzarella is your new favorite. With perfectly seasoned chicken, ribbons of tender pasta, and a luscious sauce brimming with garlic and melted cheese, this dish strikes a balance between comforting and bold. It’s weeknight friendly but special enough for guests.

The Cajun seasoning gives just the right kick to wake up your taste buds, while the trio of cheeses—Parmesan, mozzarella, and cream cheese—wraps everything in a rich, velvety finish. You’ll love how the garlic comes through in every bite, making this dish fragrant and irresistible. Plus, it’s a one-skillet wonder, meaning cleanup is just as breezy as the prep.

Why You’ll Love This Creamy Cajun Chicken Pasta

This pasta recipe hits all the marks: it’s creamy, cheesy, spicy, and filling. Whether you’re serving a cozy family dinner or meal prepping for the week, the flavors hold up beautifully. The blend of Cajun spice and melty cheese is both indulgent and deeply satisfying. Even better, it’s completely customizable—you can add veggies, swap proteins, or dial up the spice.

What Kind of Pasta Should I Use?

For this recipe, penne, rigatoni, or fettuccine work best, as they hold the creamy sauce well. If you want a rustic, hearty feel, go for rigatoni. For a smoother, silkier texture, fettuccine glides beautifully through the sauce. Avoid angel hair or spaghetti, which might get lost in the thickness of the cheese and Cajun-spiced cream.

Ingredients for the Creamy Cajun Chicken Pasta

This recipe brings together a handful of pantry staples and a few bold, flavorful ingredients that transform simple pasta into a creamy Cajun masterpiece. The secret lies in the perfect balance of spice, creaminess, and the richness of good cheese. Here are the essentials you’ll need:

• Chicken breasts – The star of the dish. Sliced thinly and seasoned generously, it becomes tender and juicy with Cajun spices.
• Cajun seasoning – Adds heat, depth, and signature Southern flavor.
• Olive oil – Used to sear the chicken and infuse the base with flavor.
• Butter – Helps develop the rich, velvety sauce.
• Garlic – Aromatic and savory, it brings warmth and depth to the creamy base.
• Heavy cream – Forms the foundation of the sauce, giving it luscious body and texture.
• Parmesan cheese – Brings saltiness and umami to balance the spice.
• Mozzarella cheese – For that gooey, melty, irresistible cheese pull.
• Cream cheese – Adds tanginess and extra creaminess.
• Pasta – Penne or fettuccine are great options that cling beautifully to the sauce.
• Salt and pepper – To season to taste and bring everything together.

How To Make the Creamy Cajun Chicken Pasta

Step 1: Season and Sear the Chicken

Slice the chicken breasts into strips and coat them evenly with Cajun seasoning. Heat olive oil in a large skillet and cook the chicken over medium-high heat until it’s browned and cooked through. Remove and set aside.

Step 2: Sauté the Garlic

In the same skillet, lower the heat slightly and add butter. Once melted, toss in the minced garlic and sauté just until fragrant. This step infuses the fat with garlicky goodness that’ll carry through the sauce.

Step 3: Build the Creamy Base

Pour in the heavy cream and stir in the cream cheese until it melts and blends smoothly. Add the Parmesan and mozzarella next, whisking until fully melted and velvety.

Step 4: Combine Chicken and Pasta

Return the cooked chicken to the skillet and add the cooked, drained pasta. Toss everything together until well coated in the sauce.

Step 5: Finish and Serve

Let everything simmer together for a couple of minutes to allow the flavors to meld. Taste and adjust salt and pepper as needed. Serve warm with a little extra Parmesan if you’d like.

How to Serve and Store Creamy Cajun Chicken Pasta

This dish is hearty enough to stand alone but works well as part of a bigger meal too. Serve it hot from the skillet with a light dusting of extra Parmesan and perhaps a sprinkle of fresh parsley for color and freshness. A crusty garlic bread or simple green salad makes it feel even more complete.

As for storage, any leftovers should be cooled and transferred into airtight containers. They keep well in the refrigerator for up to 4 days. To reheat, add a splash of milk or cream and warm it gently over the stove or in the microwave until creamy again. This recipe feeds about 4 generous servings, or 5 smaller portions if you’re pairing it with sides.

What to Serve With Creamy Cajun Chicken Pasta?

Garlic Bread

The buttery crunch of garlic bread is the perfect sidekick to this rich, cheesy pasta. It helps mop up any leftover sauce too.

Steamed Broccoli

A simple side of steamed broccoli adds a fresh and healthy contrast to the decadent main dish.

Caesar Salad

Crisp romaine, creamy dressing, and crunchy croutons create a cooling balance against the Cajun spices.

Roasted Asparagus

This lightly caramelized veggie offers a sophisticated pairing, especially when topped with lemon zest.

Southern Fried Okra

Stay on theme and serve up a basket of fried okra. The crisp coating and earthy flavor fit beautifully here.

Cornbread Muffins

Slightly sweet and crumbly, cornbread muffins are a Southern-inspired match that hold their own beside the spice.

Grilled Zucchini

Lightly charred and seasoned zucchini brings a smoky freshness that works well with the bold Cajun cream sauce.

Tomato Cucumber Salad

A chilled, zesty salad with vinegar dressing cuts through the richness and resets your palate between bites.

Want More Pasta Ideas With a Kick?

If you’re loving the flavors in this Creamy Cajun Chicken Pasta, you might fall in love with these other bold, comforting pasta recipes from Luna Meals:

• Try our Delicious Garlic Sausage Alfredo Rigatoni for a peppery, garlicky pasta dinner that’s equally creamy.
• This Quick Creamy Cajun Pasta is a great no-chicken version if you’re short on protein but still crave that Cajun flair.
• Our Creamy Mushroom Ravioli is loaded with umami and a fantastic vegetarian alternative.
• Craving shrimp instead of chicken? The Creamy Garlic Butter Shrimp Scampi Lasagna is decadence in a casserole dish.

Save This Recipe For Later

📌 Save this recipe to your Pinterest dinner board so you can find it when that creamy, cheesy, spicy craving hits.

Let me know in the comments how yours turned out. Did you make it spicier or throw in bell peppers? Any cheese swaps? I love hearing how these recipes become your own.

Explore beautifully curated health-boosting meals and comfort food favorites on Luna Meals on Pinterest and discover your next go-to dish.

Conclusion

Creamy Cajun Chicken Pasta with Parmesan, Garlic, and Mozzarella is what happens when comfort food meets bold flavor. It’s a one-pan dinner loaded with textures and richness, perfect for cozy nights or flavorful weeknight meals. Whether you’re hosting or just need something soul-satisfying, this dish delivers every time.

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