If you’re craving a dinner that packs bold Cajun flavor with a creamy, cheesy twist, this Creamy Cajun Beef Spaghetti with Three-Cheese Parmesan Sauce is just what you need. Juicy seasoned beef and perfectly cooked spaghetti are coated in a luscious sauce of Parmesan, mozzarella, and cream cheese, all elevated with a smoky Cajun kick. It’s rich, hearty, and guaranteed to warm up your evening.

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This recipe is perfect for weeknight dinners when you want something comforting yet exciting. The silky cheese sauce clings to every strand of pasta, and the Cajun spices infuse each bite with a subtle heat and depth of flavor that keeps you coming back for more.

Why You’ll Love This Creamy Cajun Beef Spaghetti

This dish strikes the perfect balance between creamy indulgence and spicy savoriness. The combination of three cheeses gives it a luxurious texture, while the Cajun seasoning adds just enough punch without being overwhelming. Best of all, it comes together quickly and makes enough to feed the whole family with ease.

What Kind of Cajun Seasoning Should I Use?

Any good-quality Cajun seasoning will work beautifully here. Some are saltier than others, so taste and adjust as you go. If you like it spicier, choose a blend with more cayenne or add an extra pinch of chili flakes. You can even make your own blend at home with paprika, garlic powder, onion powder, thyme, oregano, cayenne, salt, and pepper for a custom flavor profile.

Ingredients for the Creamy Cajun Beef Spaghetti

For this flavorful pasta dish, every ingredient plays a key role in building layers of taste and creaminess. Using fresh and high-quality components ensures your spaghetti turns out irresistibly good. Here’s what you’ll need:

Spaghetti – The base of the dish, soaking up all the sauce.
Ground beef – Adds richness and heartiness to the pasta.
Cajun seasoning – Brings smoky heat and depth to the sauce.

Cream cheese – Creates the creamy foundation of the sauce.
Parmesan cheese – Adds nutty, salty complexity.
Mozzarella cheese – Melts beautifully for that gooey texture.

Heavy cream – Makes the sauce silky and indulgent.
Butter – Enhances flavor and helps sauté the beef.
Garlic – Infuses the sauce with aromatic depth.

Salt and pepper – Essential for seasoning to taste.
Fresh parsley – For a bright garnish and color.

How To Make the Creamy Cajun Beef Spaghetti

Step 1: Cook the Pasta

Bring a large pot of salted water to a boil and cook the spaghetti according to package directions until al dente. Reserve 1/2 cup pasta water before draining.

Step 2: Brown the Beef

In a large skillet over medium-high heat, melt the butter and sauté minced garlic for about a minute. Add ground beef and cook until browned and fully cooked, breaking it into crumbles.

Step 3: Season and Build the Sauce

Sprinkle the Cajun seasoning over the beef and stir well. Add cream cheese, heavy cream, and reserved pasta water. Stir until the cream cheese melts and the sauce is smooth.

Step 4: Add the Cheese

Reduce the heat to low and mix in the Parmesan and mozzarella until melted and creamy. Adjust seasoning with salt and pepper to taste.

Step 5: Combine and Serve

Toss the drained spaghetti into the skillet, coating all the noodles in the sauce. Plate and garnish with chopped parsley before serving hot.

Serving and Storing Creamy Cajun Beef Spaghetti

This creamy Cajun beef spaghetti serves about 4 to 6 people generously, making it ideal for family dinners or small gatherings. Serve it hot straight from the skillet to enjoy the cheese sauce at its creamiest. If you have leftovers, store them in an airtight container in the refrigerator for up to 3 days. Reheat gently on the stovetop or in the microwave, adding a splash of cream or milk to loosen the sauce.

What to Serve With Creamy Cajun Beef Spaghetti?

Garlic Bread

Crispy and buttery garlic bread is a perfect side to mop up all that luscious sauce.

Green Salad

A crisp green salad with a tangy vinaigrette cuts through the richness of the dish.

Roasted Vegetables

Try roasted broccoli, asparagus, or bell peppers for a colorful and healthy addition.

Sauteed Spinach

Lightly sautéed spinach with garlic makes a quick, flavorful side.

Cornbread

A Southern-inspired cornbread pairs surprisingly well with the Cajun flavors.

Grilled Shrimp

For a surf-and-turf twist, serve with some grilled Cajun shrimp on the side.

Sparkling Lemon Water

A refreshing lemon-infused sparkling water helps cleanse the palate between bites.

Want More Pasta Ideas?

If you love this creamy Cajun beef spaghetti, you’ll probably enjoy these other favorites:

• Delicious Garlic Sausage Alfredo Rigatoni for a garlicky, comforting twist.
• Quick Creamy Cajun Pasta if you’re craving a simpler, quicker Cajun fix.
• Creamy Mushroom Ravioli with earthy, decadent flavors.
• Skirt Steak Rice Bowls with Chimichurri for a fresh, vibrant alternative.
• Easy Chicken Fried Rice for a fast and satisfying dinner option.

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And let me know in the comments how yours turned out. Did you add more spice or play around with the cheeses? Did you try ground turkey or keep it classic with beef?

I love hearing how others make these recipes their own. Questions are welcome too — let’s help each other cook better.

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Conclusion

This creamy Cajun beef spaghetti with three-cheese Parmesan sauce brings together everything you love about comfort food and bold flavors. Easy enough for a weeknight but special enough for company, it’s a dish you’ll want to make again and again.

Creamy Cajun Beef Spaghetti with Three-Cheese Parmesan Sauce