Creamy Cajun Chicken Penne Pasta with Garlic Mozzarella Sauce

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Few dishes bring together bold flavor and creamy comfort quite like this Cajun chicken penne pasta. The tender strips of chicken, coated in smoky Cajun spices, pair perfectly with al dente penne pasta. What makes this recipe stand out is the garlic mozzarella sauce that clings to every bite, rich and cheesy with just the right kick of garlic to balance the Cajun heat.

This meal feels restaurant-worthy yet is simple enough to make on a busy weeknight. The Cajun seasoning provides a spicy depth that’s mellowed by the creamy sauce, creating harmony between spice and comfort. It’s a pasta dish that will satisfy anyone craving something hearty, flavorful, and satisfying.

Why You’ll Love This Creamy Cajun Chicken Penne Pasta

This recipe checks all the boxes for flavor and texture. The pasta offers a chewy base while the chicken adds protein and substance. The Cajun seasoning brings a smoky heat that makes the dish exciting without being overwhelming. The garlic mozzarella sauce wraps it all together with a creamy, cheesy finish that feels indulgent. Whether you’re cooking for family dinner or a cozy night in, this pasta will become a go-to favorite.

What Kind of Pasta Works Best for This Dish?

Penne pasta is the star of this recipe because its ridges hold onto the sauce so well, making each bite flavorful. However, you don’t have to limit yourself to penne. Rigatoni, fusilli, or even fettuccine work wonderfully with this creamy Cajun chicken sauce. The important thing is choosing a pasta shape that can hold onto the sauce and balance the chicken pieces.

Ingredients for the Creamy Cajun Chicken Penne Pasta with Garlic Mozzarella Sauce

The magic of this dish comes from a balance of spice, creaminess, and savory notes. Each ingredient has a role to play in building the final layers of flavor that make this pasta irresistible.

• Chicken breast – Provides lean protein and absorbs the Cajun seasoning beautifully.
• Penne pasta – A sturdy pasta shape that holds onto the sauce with every bite.
• Cajun seasoning – Adds smoky heat and a kick of spice to the chicken and sauce.
• Garlic cloves – Infuses the sauce with a rich, aromatic depth.
• Mozzarella cheese – Melts into the sauce, creating creamy texture and mild cheesiness.
• Heavy cream – The base of the sauce, giving it velvety richness.
• Butter – Adds smoothness and rounds out the flavors.
• Olive oil – Helps sear the chicken and adds a subtle fruity note.
• Salt and black pepper – Essential for enhancing every flavor in the dish.
• Fresh parsley – A fresh, vibrant garnish that brightens up the creamy richness.

How To Make the Creamy Cajun Chicken Penne Pasta with Garlic Mozzarella Sauce

Step 1: Season and Cook the Chicken

Start by seasoning the chicken breast generously with Cajun seasoning, salt, and pepper. Heat olive oil in a skillet and cook the chicken until golden brown on both sides and cooked through. Remove from the pan and let it rest before slicing into strips.

Step 2: Cook the Pasta

While the chicken is cooking, bring a large pot of salted water to a boil. Add penne pasta and cook until al dente according to package instructions. Drain and set aside, reserving a little pasta water.

Step 3: Build the Garlic Mozzarella Sauce

In the same skillet used for chicken, melt butter and sauté minced garlic until fragrant. Stir in heavy cream and bring to a gentle simmer. Add mozzarella cheese and whisk until smooth and creamy. Adjust seasoning with Cajun spice, salt, and pepper. If the sauce feels too thick, add a splash of reserved pasta water.

Step 4: Combine Everything

Add the cooked pasta into the skillet and toss until well coated in sauce. Return the sliced Cajun chicken to the pan, mixing everything together so the flavors meld.

Step 5: Garnish and Serve

Finish by sprinkling fresh parsley over the top and serve hot. Each plate should get a generous helping of pasta, chicken, and plenty of creamy sauce.

Serving and Storing Creamy Cajun Chicken Penne Pasta

This pasta is best enjoyed hot and fresh, with the sauce still creamy and silky. The recipe comfortably serves four people, making it perfect for family dinners or small gatherings. Leftovers can be stored in an airtight container in the refrigerator for up to three days. When reheating, add a splash of milk or cream to restore the sauce’s smooth consistency.

What to Serve With Creamy Cajun Chicken Penne Pasta?

Pairing this pasta with the right sides and accompaniments elevates the entire meal. Here are some great ideas:

Garlic Bread

The ultimate companion for any creamy pasta, garlic bread is perfect for soaking up the leftover sauce.

Caesar Salad

A crisp Caesar salad balances the richness of the pasta with its tangy dressing and crunchy croutons.

Roasted Vegetables

Roasted broccoli, zucchini, or bell peppers add color and extra nutrition to your meal.

Caprese Salad

Fresh tomatoes, mozzarella, and basil offer a refreshing contrast to the creamy, spiced pasta.

Steamed Asparagus

Light and tender asparagus spears complement the Cajun flavors without overpowering them.

Bruschetta

Toasted bread topped with fresh tomatoes, basil, and olive oil brings a light, zesty starter before the main course.

Spinach and Artichoke Dip

A warm, cheesy appetizer that pairs beautifully with pasta night.

Grilled Shrimp

For a surf-and-turf twist, grilled shrimp seasoned lightly with Cajun spices makes an excellent side.

Want More Pasta Ideas with a Kick?

If this creamy Cajun chicken penne pasta won your heart, you’ll love exploring other pasta dishes that bring bold flavors and creamy textures. Check out these flavorful creations from Luna Meals:

• Quick Creamy Cajun Pasta for another Cajun-inspired option with fast prep.
• Delicious Garlic Sausage Alfredo Rigatoni for a smoky, garlicky twist on Alfredo.
• Creamy Garlic Butter Shrimp Scampi Lasagna for seafood lovers craving indulgence.
• Rattlesnake Pasta if you’re looking for a spicy Southern-inspired pasta dish.
• Cowboy Butter Chicken Linguine for a buttery, savory flavor explosion.

Save This Recipe For Later

📌 Save this recipe to your Pinterest pasta board so you can return to it anytime you need comfort food with a spicy twist.

I’d love to hear how your pasta turned out. Did you add extra Cajun seasoning for more heat? Did you melt in some Parmesan alongside mozzarella? Share your version in the comments and inspire others.

Explore beautifully curated health-boosting drinks and more delicious recipes on Luna Meals on Pinterest and discover your next kitchen favorite.

Conclusion

Creamy Cajun chicken penne pasta with garlic mozzarella sauce is a celebration of flavor and comfort in every forkful. With its perfect balance of spice, creaminess, and cheesy richness, it’s bound to become a regular at your dinner table. Whether you make it for a quick weeknight meal or a cozy weekend treat, this dish proves that pasta night never has to be boring.

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