Creamy Cajun Chicken Fettuccine with Garlic Mozzarella Cheese Sauce

WANT TO SAVE THIS RECIPE?

This Creamy Cajun Chicken Fettuccine is everything comfort food should be—rich, savory, just the right touch of heat, and loaded with cheesy goodness. The Cajun-spiced chicken brings smoky, bold flavor that gets balanced beautifully by a velvety mozzarella cheese sauce infused with garlic. It’s the kind of dish that feels fancy but is secretly super easy to pull off on a weeknight.

From the moment the Cajun aroma hits your skillet to the final twirl of pasta on your fork, this meal is a sensory experience. The mozzarella melts seamlessly into the garlicky cream, coating each fettuccine strand in irresistible flavor. Whether you’re feeding a hungry family or hosting friends, this pasta delivers serious wow factor without the stress.

Why You’ll Love This Creamy Cajun Chicken Fettuccine

This dish is bold yet creamy, with a savory Cajun seasoning that wakes up the taste buds in the best way. The sauce isn’t your average Alfredo—it’s loaded with garlic and melty mozzarella that clings to every bite. You get spice, comfort, and cheesy indulgence all in one bowl. Plus, it takes under 40 minutes from start to finish.

It also makes fantastic leftovers, so don’t worry if you overestimate how much fettuccine you’ll need. One bite and you’ll want it again tomorrow.

What Kind of Chicken Works Best for Cajun Pasta?

Boneless, skinless chicken breasts are the most straightforward option, but chicken thighs are also a flavorful alternative. The dark meat stays juicy and tender, especially with the Cajun spice rub. If you’re in a pinch, leftover rotisserie chicken or pre-cooked grilled chicken strips can be tossed in at the end for a faster version.

Ingredients for the Creamy Cajun Chicken Fettuccine

This flavorful pasta dish comes together with pantry staples and a few fresh ingredients. Each item plays a key role in building the rich, creamy, and spicy profile that makes this fettuccine stand out.

• Fettuccine pasta
• Chicken breasts
• Cajun seasoning
• Olive oil
• Garlic cloves
• Heavy cream
• Mozzarella cheese
• Parmesan cheese
• Butter
• Salt and pepper

How To Make the Creamy Cajun Chicken Fettuccine

Step 1: Season and Sear the Chicken

Coat the chicken breasts in Cajun seasoning until evenly coated. Heat olive oil in a skillet over medium heat and sear the chicken on both sides until golden and cooked through. Remove and let rest.

Step 2: Boil the Pasta

Bring a pot of salted water to a boil and cook the fettuccine until al dente. Reserve some pasta water, then drain and set aside.

Step 3: Make the Garlic Mozzarella Sauce

In the same skillet, melt butter and sauté minced garlic until fragrant. Pour in the heavy cream and let it simmer, then slowly add shredded mozzarella and grated Parmesan. Stir until smooth and creamy.

Step 4: Combine Everything

Slice the chicken and return it to the skillet. Toss in the cooked fettuccine and a splash of reserved pasta water if needed. Stir to coat everything in the sauce.

Step 5: Serve Hot

Season with salt and pepper to taste. Garnish with extra Parmesan or parsley and serve hot.

How to Serve and Store Creamy Cajun Chicken Fettuccine

This pasta dish is at its absolute best served hot from the skillet, with the cheese still gooey and the chicken fresh off the pan. You can plate it in shallow pasta bowls to allow the sauce to pool slightly, giving every forkful that creamy goodness. It comfortably feeds 4 to 5 people, making it a satisfying dinner for family nights or when entertaining guests.

Leftovers can be stored in an airtight container in the refrigerator for up to 3 days. To reheat, add a splash of milk or cream in a skillet over low heat and stir gently until warmed through. The sauce will loosen up and regain its velvety texture.

What to Serve With Creamy Cajun Chicken Fettuccine?

Garlic Bread

Crispy, buttery garlic bread is a must. It’s perfect for scooping up any leftover sauce and adds a crunchy contrast to the creamy pasta.

Simple Green Salad

A refreshing green salad with a light vinaigrette balances out the richness of the fettuccine.

Roasted Broccoli

Oven-roasted broccoli brings a smoky, earthy flavor that pairs nicely with Cajun spice.

Grilled Asparagus

Bright and slightly charred asparagus spears add texture and freshness.

Creamed Spinach

A double dose of creamy with a subtle earthy undertone that complements the mozzarella sauce.

Cajun Shrimp Skewers

If you’re feeding a crowd, add some Cajun-spiced shrimp skewers on the side for extra protein.

Cornbread Muffins

Slightly sweet, soft cornbread muffins make a unique and satisfying pairing.

Lemon Iced Tea

To wash it all down, a chilled glass of lemon iced tea helps cut through the richness with a citrusy zing.

Want More Chicken Pasta Ideas?

If you loved this Creamy Cajun Chicken Fettuccine, these other recipes might just become your next favorite dinner:

• Try our Delicious Garlic Sausage Alfredo Rigatoni for a rich and meaty twist on classic Alfredo.
• Our Easy Chicken Fried Rice makes the perfect fast and flavorful weeknight meal.
• Explore the bold layers in our Rattlesnake Pasta Recipe for a spicy, cheesy experience.
• Lighten it up with Light Lemon Basil Pasta Salad with Chicken for fresh flavors and easy prep.
• Or add Southern comfort to your table with Smothered Chicken and Rice.

Save This Recipe For Later

📌 Save this recipe to your Pinterest dinner board so you can come back to it any time.

And let me know in the comments how yours turned out. Did you spice it up more? Try a different cheese? Or maybe added veggies?

I love hearing how others make these recipes their own. Questions are welcome too—let’s help each other cook smarter.

Explore beautifully curated health-boosting dinners and comfort meals on Luna Meals on Pinterest and discover your new go-to dishes.

Conclusion

Creamy Cajun Chicken Fettuccine is the kind of dinner that delivers bold flavor and comfort in every bite. It takes simple ingredients and turns them into a cheesy, garlicky, and deeply satisfying meal. Perfect for weeknights or special gatherings, this dish is sure to become a favorite in your home. Don’t be surprised if it makes its way into your regular rotation.

Print

WANT TO SAVE THIS RECIPE?