Chicken Bubble Biscuit Bake Casserole

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If you’re craving a comforting and cozy dish that brings together the magic of buttery biscuits, creamy sauce, and juicy chicken, the Chicken Bubble Biscuit Bake Casserole is going to become a favorite in your home. This dish is like the potluck hero and weeknight savior all in one. Each bite gives you a buttery biscuit puff soaked in creamy chicken goodness, paired with melted cheese and a satisfying touch of seasoning.

The best part is how simple it is to pull together. You don’t need hours of prep or a sink full of dishes. With store-bought ingredients and minimal effort, you’ll have a hearty, hot-from-the-oven casserole that feels like home. It’s a crowd-pleaser, freezer-friendly, and totally family-approved.

Why You’ll Love This Chicken Bubble Biscuit Bake Casserole

This bake hits all the notes of a satisfying comfort meal. The biscuit pieces bubble up and soak in the creamy mixture, creating fluffy, golden pockets of joy. The shredded chicken brings protein while the creamy soup base holds everything together in savory perfection. It’s perfect for busy evenings, cozy weekends, or lazy Sunday brunches. Plus, it feeds a crowd and reheats beautifully.

What Kind of Biscuits Should I Use?

Refrigerated canned biscuits are the easiest and most effective choice here. Use the regular-size biscuits and cut them into quarters before mixing. Avoid flaky layers or jumbo versions as they might not cook evenly or fully absorb the flavors. Pillsbury-style buttermilk biscuits are perfect for this casserole, as they puff up beautifully without overpowering the dish.

Ingredients for the Chicken Bubble Biscuit Bake Casserole

This recipe comes together with just a few pantry staples. It’s incredibly forgiving, and you can always swap in what you have on hand.

Canned biscuits are the base of this recipe, giving the casserole its signature “bubble” texture. Once quartered, they puff up and absorb all the creamy flavor.

Cooked chicken adds protein and turns this into a complete meal. Rotisserie chicken or any leftover cooked chicken works perfectly.

Cream of chicken soup brings a creamy base that binds everything together. It creates the signature casserole feel with minimal fuss.

Sour cream adds tang and richness to the mix, elevating the flavor and balancing the saltiness.

Shredded cheddar cheese melts into gooey deliciousness and adds sharpness to each bite.

Milk helps thin the mixture just enough to coat everything evenly without getting soupy.

Garlic powder and onion powder add savory depth and aroma.

Salt and black pepper round out the flavor and ensure the seasoning pops.

How To Make the Chicken Bubble Biscuit Bake Casserole

Step 1: Prep Your Ingredients

Preheat your oven to 350°F. Grease a 9×13-inch baking dish. Cut each biscuit into quarters and set aside. Shred your cooked chicken if you haven’t already.

Step 2: Make the Creamy Base

In a large mixing bowl, stir together the cream of chicken soup, sour cream, milk, garlic powder, onion powder, salt, and pepper. Mix until well combined.

Step 3: Combine Biscuits and Chicken

Add the cooked, shredded chicken and quartered biscuit pieces into the creamy mixture. Stir to coat evenly.

Step 4: Assemble the Casserole

Pour everything into the greased baking dish. Spread it out evenly, then sprinkle the shredded cheddar cheese across the top.

Step 5: Bake Until Golden and Bubbly

Place the dish in the oven and bake for 30 to 35 minutes, or until the biscuits are golden brown and cooked through. Let it rest for 5 minutes before serving.

How to Serve and Store This Cozy Casserole

This casserole is best served warm and fresh out of the oven, when the biscuits are still puffed and the cheese is melty. It feeds about 6 people generously, making it perfect for family dinners or casual gatherings. If you end up with leftovers, store them in an airtight container in the fridge for up to 3 days. You can reheat individual portions in the microwave, or warm the whole dish in the oven covered with foil.

If you’d like to freeze it, assemble the casserole up to the point before baking. Wrap tightly and freeze for up to 2 months. When ready to bake, let it thaw in the fridge overnight, then bake as directed.

What to Serve With Chicken Bubble Biscuit Bake Casserole?

Garden Salad with Tangy Vinaigrette

The richness of the casserole pairs beautifully with a crisp, refreshing salad to cut through the creaminess.

Roasted Green Beans

Their slight crunch and charred edges make a perfect sidekick to the softness of the bake.

Honey-Glazed Carrots

For a pop of natural sweetness and color on the plate, these carrots are a wholesome complement.

Southern-Style Coleslaw

The crunch and acidity of slaw offer a lovely balance, especially if you like a bit of zip.

Garlic Butter Corn on the Cob

Simple and flavorful, this classic side rounds out the meal with minimal effort.

Sautéed Spinach or Kale

If you want to sneak in some greens, sautéed spinach with garlic brings nutrition without overpowering the flavors.

Cranberry Sauce or Relish

This unexpected twist adds tart contrast and is especially delightful around the holidays.

Apple Slices or Pear Wedges

For a super light and fresh bite after the casserole, some fruit on the side or as dessert is perfect.

Want More Casserole Ideas?

If this cozy dinner bake speaks your language, try diving into these other delicious casseroles:

• Smothered Chicken and Rice for creamy comfort with a southern twist.
• Amish Sunday Savior Casserole that delivers hearty satisfaction.
• Low-Carb Chicken Casserole for a lighter version without losing flavor.
• Crockpot Loaded Steak and Potato Bake if you love slow-cooked indulgence.
• Cowboy Butter Chicken Linguine for bold, buttery, pasta-filled comfort.

Save This Recipe For Later

📌 Save this recipe to your Pinterest comfort food board so you can find it when you need something cozy and satisfying.

And let me know in the comments how yours turned out. Did you add veggies or spice it up with jalapeños? Did you try it with leftover turkey?

I always love hearing how you make Luna Meals your own. Don’t hesitate to share your tweaks or ask questions—we’re all here to eat well together.

Explore more cozy comfort food and hearty casseroles on Luna Meals on Pinterest—your daily dose of flavor inspiration.

Conclusion

Chicken Bubble Biscuit Bake Casserole is more than a recipe—it’s a go-to dish you can always count on. With just a handful of ingredients and minimal effort, you can bring a warm, flavorful, and totally comforting dinner to the table. Whether you’re feeding a busy family or treating yourself to a satisfying weekend bake, this one hits all the right notes.

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